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The Rise of Three Rs Centres and Platforms in Europe

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Public awareness and discussion about animal experiments and replacement methods has greatly increased in recent years.

DOI: 
https://journals.sagepub.com/doi/10.1177/02611929221099165

Microfluidics for 3D Cell and Tissue Cultures: Microfabricative and Ethical Aspects Updates

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The necessity to improve in vitro cell screening assays is becoming ever more important.

DOI: 
10.3390/cells11101699

Somatostatin, a Presynaptic Modulator of Glutamatergic Signal in the Central Nervous System

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Somatostatin is widely diffused in the central nervous system, where it participates to controlthe efficiency of synaptic transmission.

An Innovative In Vitro Open‐Angle Glaucoma Model (IVOM) Shows Changes Induced by Increased Ocular Pressure and Oxidative Stress

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Primary Open‐Angle Glaucoma (POAG) is a neurodegenerative disease, and its clinical outcomes lead to visual field constriction and blindness. POAG’s etiology is very complex and its

DOI: 
https://doi.org/10.3390/ ijms222212129

Scaling of joint mass and metabolism fluctuations in in silico cell-laden spheroids

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Lo scaling allometrico ha molte applicazioni, dalla predizione della cinetica dei farmaci negli animali all'uomo allo studio della dinamica degli ecosistemi.

DOI: 
https://doi.org/10.1073/pnas.2025211118

Lipoperoxide Nanoemulsion as Adjuvant in Cisplatin Cancer Therapy: In Vitro Study on Human Colon Adenocarcinoma DLD-1 Cells

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Cisplatin is a first-choice chemotherapeutic agent used to treat solid tumors even though the onset of multi-drug resistance and the time–dose side-effects impair its mono-therapeutic application.

DOI: 
https://doi.org/10.3390/nano11061365

A novel 3D in vitro model of the human gut microbiota

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Lo studio del microbiota umano è limitato dalla difficolta' di accesso all'intestino in maniera non invasiva.

DOI: 
https://doi.org/10.1038/s41598-020-78591-w

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