Centro3R | Centro Interuniversitario per la Promozione dei Principi delle 3R nella Didattica e nella Ricerca

Centro Interuniversitario per la Promozione dei Principi delle 3R nella Didattica e nella Ricerca

REFINEMENT

miglioramento dei disegni sperimentali per diminuire lo stress e la sofferenza agli animali

REPLACEMENT

sostituzione della sperimentazione animale con metodi alternativi di equiparabile o migliore validità e valore traslazionale

REDUCTION

riduzione del numero degli animali usati per uno studio specifico

Publications

Lipoperoxide Nanoemulsion as Adjuvant in Cisplatin Cancer Therapy: In Vitro Study on Human Colon Adenocarcinoma DLD-1 Cells

Lingua EN

Cisplatin is a first-choice chemotherapeutic agent used to treat solid tumors even though the onset of multi-drug resistance and the time–dose side-effects impair its mono-therapeutic application.

DOI:

https://doi.org/10.3390/nano11061365

A novel 3D in vitro model of the human gut microbiota

Lingua Undefined

Lo studio del microbiota umano è limitato dalla difficolta' di accesso all'intestino in maniera non invasiva.

DOI:

https://doi.org/10.1038/s41598-020-78591-w

Wall Shear Stress Topological Skeleton Independently Predicts Long-Term Restenosis After Carotid Bifurcation Endarterectomy

Lingua Undefined

Morbiducci U, Mazzi V, Domanin M, De Nisco G, Vergara C, Steinman DA, Gallo D.

DOI:

10.1007/s10439-020-02607-9

Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A

Lingua Undefined

Terreni E, Chetoni P, Tampucci S, Burgalassi

DOI:

10.3390/pharmaceutics12030253

A low-cost scalable 3D-printed sample-holder for agitation-based decellularization of biological tissues

Lingua Undefined

Carbonaro D, Putame G, Castaldo C, Meglio FD, Siciliano K, Belviso I, Romano V, Sacco AM, Schonauer F, Montagnani S, Audenino AL, Morbiducci U, Gallo D, Massai D.

DOI:

10.1016/j.medengphy.2020.09.006

News

31 Dicembre 2021

Alternative Methods to Animal Testing on the Assessment of Drug Permeation Across Different Barriers, Focusing on the Skin and Eye

The number of animals used in research has significantly increased with the advancement of sciences and the development of medical technology.

03 Ottobre 2021

Intervista ad Anna Maria Bassi su Kosmetica

La transizione ecologica passa anche dalla ricerca biomedicale!

Publications

Lipoperoxide Nanoemulsion as Adjuvant in Cisplatin Cancer Therapy: In Vitro Study on Human Colon Adenocarcinoma DLD-1 Cells

A novel 3D in vitro model of the human gut microbiota

Wall Shear Stress Topological Skeleton Independently Predicts Long-Term Restenosis After Carotid Bifurcation Endarterectomy

Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A

A low-cost scalable 3D-printed sample-holder for agitation-based decellularization of biological tissues

News

Special Issue "Towards 3R Approaches: Bioengineering Tools and Technologies as Advanced Alternatives to Animal Testing"

Vanessa Almonti vince il premio IPAM 2021

“Organoids and disease modeling”

Invitation for the Special Issue "In Vitro Model for Micro and Nano Technologies"

Alternative Methods to Animal Testing on the Assessment of Drug Permeation Across Different Barriers, Focusing on the Skin and Eye

Intervista ad Anna Maria Bassi su Kosmetica